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Operation of the pathway in vivo: unresolved issues The ascorbateglutathione pathway as understood today does not easily lend itself to the use of nuclear isotopes to estimate metabolic flux between the different reactions

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A recent study found that low-intensity (0.5 mA) acupuncture stimulation at Zusanli acupoint (ST36) is sufficient to activate the vagus nerve adrenal NPY + medullary cells pathway, while the high-intensity (3 mA) acupuncture stimulation at Zusanli (ST36) can activate the spinal cord sympathetic reflex [130, 131]